HUMAN RESPONSES TO INHALED CAPSAICIN ARE NOT INHIBITED BY GRANISETRON

被引：9
作者：
CHOUDRY, NB
MCEWAN, JR
LAVENDER, EA
WILLIAMS, AJ
FULLER, RW
机构：
[1] ROYAL POSTGRAD MED SCH,DEPT CLIN PHARMACOL,DUCANE RD,LONDON W12 0NN,ENGLAND
[2] SMITHKLINE BEECHAM PHARMACEUT,BIOSCI RES CTR,EPSOM KT18 5XQ,SURREY,ENGLAND
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 31卷 / 03期
关键词：
5-HT; COUGH; REFLEX BRONCHOCONSTRICTION;
D O I：
10.1111/j.1365-2125.1991.tb05538.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cough is a common respiratory symptom, the mechanism of which is poorly understood. In this study the role of 5-HT3 receptors was investigated. Capsaicin-induced cough and increase in airways resistance were measured in six male volunteers before and after infusion with granisetron 160-mu-g kg-1 or placebo. Neither cough nor the increase in respiratory resistance was altered by the active treatment. These results suggest that 5-HT3 receptors are not involved in these two respiratory responses to inhaled capsaicin in humans.
引用
收藏
页码：337 / 339
页数：3
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