POLYMORPHONUCLEAR LEUKOCYTE-DEPENDENT MODULATION OF PLATELET-FUNCTION - EFFECT OF CLORICROMENE

被引：11
作者：
ZATTA, A
PROSDOCIMI, M
BAZZONI, G
DEJANA, E
DELMASCHIO, A
机构：
[1] FIDIA RES LABS,VIA PONTE FABBR 3-A,I-35031 ABANO TERME,ITALY
[2] MARIO NEGRI INST PHARMACOL RES,VASC BIOL LAB,I-20157 MILAN,ITALY
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 198卷 / 01期
关键词：
PLATELET-POLYMORPHONUCLEAR LEUKOCYTE INTERACTION; CLORICROMENE;
D O I：
10.1016/0014-2999(91)90568-B
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cloricromene inhibits the activation of platelets and polymorphonuclear leukocytes (PMN) induced by specific stimuli. We report here that cloricromene caused a concentration-dependent reduction of platelet aggregation, beta-thromboglobulin (beta-TG) release and cytoplasmic Ca2+ movements induced by PMN stimulated with N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP), and enhanced the inhibitory action of unstimulated PMN on platelet responses to the stable endoperoxide analog U46619. These effects may be of pharmacological interest in view of the multiple interactions between platelets and leukocytes that occur in thrombotic and inflammatory diseases.
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收藏
页码：97 / 100
页数：4
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