SYNTHESIS OF [C-11] METHYL MAGNESIUM IODIDE AND ITS APPLICATION TO THE INTRODUCTION OF [C-11] N-TERT-BUTYL GROUPS AND [C-11]-SEC-ALCOHOLS

The C-11 labelled Grignard reagent methyl magnesium iodide was synthesized carrier and non-carrier added from [C-11]methyl iodide and magnesium. This new C-11-synthon was applied in the synthesis of a [C-11]-N-tert-butyl group by reaction with 2,2,3,4-tetramethyl-5-phenyl-oxazolidine and in the synthesis of C-11-sec-alcohols by reaction with benzaldehyde and 3-phenylpropionaldehyde. The radiochemical yield was 18-29% (not corrected for decay) with a synthesis time of 18 min (from [C-11]CH3I). In the case of 2,2,3,4-tetramethyl-5-phenyl-oxazolidine an one-pot synthesis was developed according to the Barbier method.