ACUTE EFFECTS OF INSULIN-LIKE GROWTH FACTOR-I (IGF-I) ON BONE PROTEIN-SYNTHESIS IN RATS

被引：1
作者：
MARTINEZ, AJ
PASCUAL, M
LARRALDE, J
机构：
[1] Department of Physiology and Nutrition, University of Navarra
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 1994年 / 1199卷 / 01期
关键词：
INSULIN-LIKE GROWTH FACTOR-I; IGF-I; GROWTH HORMONE; BONE GROWTH; PROTEIN SYNTHESIS;
D O I：
10.1016/0304-4165(94)90103-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The acute systemic effects of IGF-I on bone protein metabolism from hormonally intact rats have been investigated by measuring the fractional rate of protein synthesis. The animals received a single subcutaneous injection of rhIGF-I (100 mu g). Treatment with IGF-I increased the rate of tibia protein synthesis (Ks) while plasma glucose and insulin concentrations were decreased. These results art in favor of an endocrine role of IGF in stimulating bone growth.
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收藏
页码：101 / 103
页数：3
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