OLEYLAMINE AND STEARYLAMINE INCREASE PHOSPHATIDYLSERINE SYNTHESIS IN T-CELLS BY SYNERGY WITH CALCIUM-IONS

被引：11

作者：

AUSSEL, C

PELASSY, C

BERNARD, A

机构：

[1] INSERM U343, Hôpital de l'Archet, 06202 Nice Cédex 03

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1995年 / 27卷 / 06期

基金：

澳大利亚研究理事会;

关键词：

PHOSPHATIDYLSERINE; CALCIUM; OLEYLAMINE; STEARYLAMINE; T CELLS;

D O I：

10.1016/1357-2725(95)00016-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oleylamine and stearylamine, two cationic amphiphilic drugs, strongly increase phosphatidylserine synthesis in human T cells. The two compounds had little effect on either phosphatidylcholine or phosphatidylethanolamine synthesis. A decrease in the formation of phosphatidylethanolamine through decarboxylation of phosphatidylserine was observed, but this effect is only marginally involved in increased phosphatidylserine synthesis, The high incorporation of [H-3]-serine into phosphatidylserine is a protein kinase C independent process and is due to a synergy of either oleylamine or stearylamine with calcium ions.

引用

页码：597 / 602

页数：6

共 18 条

[1] SIDEDNESS OF PHOSPHATIDYLCHOLINE-SYNTHESIZING ENZYMES IN RAT-BRAIN MICROSOMAL VESICLES [J].