THE EFFECT OF BETA,BETA'-TETRAMETHYLHEXADECANEDIOIC ACID (MEDICA-16) ON PLASMA VERY-LOW-DENSITY LIPOPROTEIN METABOLISM IN RATS - ROLE OF APOLIPOPROTEIN C-III

被引：22

作者：

FRENKEL, B ^{[1
]}

BISHARASHIEBAN, J ^{[1
]}

BARTANA, J ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM,HADASSAH FAC MED,DEPT HUMAN NUTR & METAB,IL-1172 JERUSALEM,ISRAEL

来源：

BIOCHEMICAL JOURNAL | 1994年 / 298卷

关键词：

D O I：

10.1042/bj2980409

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Short term treatment of rats with beta,beta'-tetramethylhexadecanedioic acid (MEDICA 16) results in a pronounced decrease in plasma very-low-density-lipoprotein (VLDL) cholesterol and VLDL triacylglycerol, previously ascribed to a decrease in liver VLDL production [Bar-Tana, Rose-Kahn, Frenkel, Shafer and Fainaru (1988) J. Lipid Res. 29, 431-441]. The hypolipidaemic effect of MEDICA 16 was further analysed here by monitoring plasma VLDL clearance and its hepatic uptake. VLDL triacylglycerol and VLDL apolipoprotein (apo) B fractional clearance rates were increased 7-8-fold in MEDICA 16-treated rats. The increase in the fractional clearance rate of plasma VLDL was essentially eliminated by functional hepatectomy. It was accounted for by activation of plasma VLDL uptake by the liver being completed during the first 4 min after the injection of the VLDL label and before commencement of uptake in non-treated animals. The hypolipidaemic effect of MEDICA 16 was accompanied by a 3.5-fold decrease in plasma apoC-III, but plasma apoC-III clearance remained unaffected by MEDICA 16. MEDICA 16-induced premature hepatic uptake of plasma VLDL due to suppression of apoC-III production may thus account for enhancement of plasma VLDL clearance in treated animals.

引用

页码：409 / 414

页数：6

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