CHONDROITIN SULFATE PROTEOGLYCANS ARE A COMMON COMPONENT OF NEURONAL INCLUSIONS AND ASTROCYTIC REACTION IN NEURODEGENERATIVE DISEASES

被引：65

作者：

DEWITT, DA ^{[1
]}

RICHEY, PL ^{[1
]}

PRAPROTNIK, D ^{[1
]}

SILVER, J ^{[1
]}

PERRY, G ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV, DEPT NEUROSCI, CLEVELAND, OH 44106 USA

来源：

BRAIN RESEARCH | 1994年 / 656卷 / 01期

关键词：

ALZHEIMERS DISEASE; ASTROCYTE; CYTOSKELETON; EXTRACELLULAR MATRIX; HUNTINGTONS DISEASE; IMMUNOCYTOCHEMISTRY; PARKINSONS DISEASE;

D O I：

10.1016/0006-8993(94)91386-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previously, we showed three differentially sulfated forms of chondroitin sulfate proteoglycans (CSPG) associated with senile plaques, astrocytes and neurofibrillary tangles in Alzheimer's disease. Here, monoclonal antibodies were used to demonstrate CSPGs in other neurodegenerative diseases. CSPGs were found associated with inclusions of Parkinson's, diffuse Lewy body, Pick's diseases, and progressive supranuclear palsy. Reacting astrocytes in each of these neurodegenerative diseases and Huntington's disease showed immunoreactivity far CSPG. CSPG distribution in a variety of neurodegenerative diseases suggests that similar mechanisms may be involved in the accumulation of proteoglycans in a number of filamentous inclusions.

引用

页码：205 / 209

页数：5

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