PHARMACOKINETIC OPTIMIZATION OF TRICYCLIC ANTIDEPRESSANT THERAPY

被引:31
作者
FURLANUT, M
BENETELLO, P
SPINA, E
机构
[1] UNIV PADUA,FAC MED,INST NEUROL,I-35100 PADUA,ITALY
[2] UNIV MESSINA,FAC MED,INST PHARMACOL,I-98100 MESSINA,ITALY
关键词
D O I
10.2165/00003088-199324040-00004
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Pharmacokinetics has greatly contributed to the elucidation of the variability in clinical response to antidepressants in terms of differences in plasma concentrations due to genetic constitution, age, associated diseases and drug interactions. Despite no general agreement, therapeutic and toxic concentrations have been suggested for some tricyclic antidepressants (TCAs) [amitriptyline, nortriptyline, imipramine, desipramine]. Predictive techniques may be implemented on the basis of which starting TCA dosages may be selected to reach more rapidly those concentrations at which efficacy is more probable. Therapeutic drug monitoring may thereafter assist the clinician in refining the individualisation of the dosage regimen.
引用
收藏
页码:301 / 318
页数:18
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