POTENTIATION BY THE BETA-SUBUNIT OF THE RATIO OF THE IONIC CURRENT TO THE CHARGE MOVEMENT IN THE CARDIAC CALCIUM-CHANNEL

被引：222

作者：

NEELY, A

WEI, XY

OLCESE, R

BIRNBAUMER, L

STEFANI, E

机构：

[1] BAYLOR COLL MED, DEPT CELL BIOL, HOUSTON, TX 77030 USA

[2] BAYLOR COLL MED, DEPT MED ENDOCRINOL, HOUSTON, TX 77030 USA

[3] BAYLOR COLL MED, DIV NEUROSCI, HOUSTON, TX 77030 USA

[4] BAYLOR COLL MED, DEPT NEUROL, HOUSTON, TX 77030 USA

来源：

SCIENCE | 1993年 / 262卷 / 5133期

关键词：

D O I：

10.1126/science.8211185

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The voltage-activated rabbit cardiac calcium channel alpha1 subunit was expressed in Xenopus oocytes. The charge movement of its voltage sensor was measured and related to the opening of the ion-conducting pore. The half-activation potential for charge movement was 35 millivolts more negative than that for pore opening. Coexpression of the cardiac calcium channel beta subunit reduced this difference without affecting charge movement. Thus, intramolecular coupling between the voltage sensor and the channel pore opening can be facilitated by a regulatory subunit.

引用

页码：575 / 578

页数：4

共 19 条

[1] INTRAMEMBRANE CHARGE MOVEMENT RESTORED IN DYSGENIC SKELETAL-MUSCLE BY INJECTION OF DIHYDROPYRIDINE RECEPTOR CDNAS [J].