EFFECTS OF CROCUS-SATIVUS L ON THE ETHANOL-INDUCED IMPAIRMENT OF PASSIVE-AVOIDANCE PERFORMANCES IN MICE

被引：0
|
作者：
ZHANG, YX
SHOYAMA, Y
SUGIURA, M
SAITO, H
机构：
[1] UNIV TOKYO, FAC PHARMACEUT SCI, DEPT CHEM PHARMACOL, BUNKYO KU, TOKYO 113, JAPAN
[2] KYUSHU UNIV, FAC PHARMACEUT SCI, DEPT PHARMACOGNOSY, HIGASHI KU, FUKUOKA 812, JAPAN
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1994年 / 17卷 / 02期
关键词：
CROCUS SATIVUS; ETHANOL; PASSIVE AVOIDANCE PERFORMANCE; SEDATIVE EFFECT;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The acute effects of an alcohol extract of Crocus sativus L. (CS-extract) were studied on learning and memory in step through (ST) and step down (SD) tests in normal as well as in learning- and memory-impaired mice. A single oral administration of CS-extract had no effects on memory regist ation, consolidation or retrieval in normal mice. CS-Extract reduced the ethanol-induced impairment of memory registration both in ST and SD tests and the ethanol-induced impairment of memory retrieval in SD test. CS-Extract decreased the motor activity (MA) and prolonged the sleeping time induced by hexobarbital. These results suggested that CS-extract ameliorates the impairment effects of ethanol on learning and memory processes, and possesses a sedative effect.
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页码：217 / 221
页数：5
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