MACROH2A, A CORE HISTONE CONTAINING A LARGE NONHISTONE REGION

被引：0
|
作者：
PEHRSON, JR
FRIED, VA
机构：
[1] NEW YORK MED COLL,DEPT CELL BIOL & ANAT,VALHALLA,NY 10595
[2] FOX CHASE CANC INST,INST CANC RES,PHILADELPHIA,PA 19111
来源：
SCIENCE | 1992年 / 257卷 / 5075期
关键词：
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A histone, macroH2A, nearly three times the size of conventional H2A histone, was found in rat liver nucleosomes. Its N-terminal third is 64 percent identical to a full-length mouse H2A. However, it also contains a large nonhistone region. This region has a segment that resembles a leucine zipper, a structure known to be involved in dimerization of some transcription factors. Nucleosomes containing macroH2A may have novel functions, possibly involving interactions with other nuclear proteins.
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页码：1398 / 1400
页数：3
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