MACROH2A, A CORE HISTONE CONTAINING A LARGE NONHISTONE REGION

被引：0
|
作者：
PEHRSON, JR
FRIED, VA
机构：
[1] NEW YORK MED COLL,DEPT CELL BIOL & ANAT,VALHALLA,NY 10595
[2] FOX CHASE CANC INST,INST CANC RES,PHILADELPHIA,PA 19111
来源：
SCIENCE | 1992年 / 257卷 / 5075期
关键词：
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A histone, macroH2A, nearly three times the size of conventional H2A histone, was found in rat liver nucleosomes. Its N-terminal third is 64 percent identical to a full-length mouse H2A. However, it also contains a large nonhistone region. This region has a segment that resembles a leucine zipper, a structure known to be involved in dimerization of some transcription factors. Nucleosomes containing macroH2A may have novel functions, possibly involving interactions with other nuclear proteins.
引用
收藏
页码：1398 / 1400
页数：3
相关论文
共 50 条
  • [31] Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation
    Csankovszki, G
    Panning, B
    Bates, B
    Pehrson, JR
    Jaenisch, R
    NATURE GENETICS, 1999, 22 (04) : 323 - 324
  • [32] MacroH2A - An epigenetic regulator of cancer
    Cantarino, Neus
    Douet, Julien
    Buschbeck, Marcus
    CANCER LETTERS, 2013, 336 (02) : 247 - 252
  • [33] The histone variant macroH2A suppresses melanoma progression through regulation of CDK8
    Avnish Kapoor
    Matthew S. Goldberg
    Lara K. Cumberland
    Kajan Ratnakumar
    Miguel F. Segura
    Patrick O. Emanuel
    Silvia Menendez
    Chiara Vardabasso
    Gary LeRoy
    Claudia I. Vidal
    David Polsky
    Iman Osman
    Benjamin A. Garcia
    Eva Hernando
    Emily Bernstein
    Nature, 2010, 468 : 1105 - 1109
  • [34] Functional Analysis of the MacroH2A Histone Variant During Zebrafish (Danio rerio) Development
    Ines Guajardo, Laura
    Munoz, Valentina
    Bouvet, Philippe
    Molina, Alfredo
    Alvarez, Marco
    FASEB JOURNAL, 2009, 23
  • [35] MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms
    Kozlowski, Marek
    Corujo, David
    Hothorn, Michael
    Guberovic, Iva
    Mandemaker, Imke K.
    Blessing, Charlotte
    Sporn, Judith
    Gutierrez-Triana, Arturo
    Smith, Rebecca
    Portmann, Thomas
    Treier, Mathias
    Scheffzek, Klaus
    Huet, Sebastien
    Timinszky, Gyula
    Buschbeck, Marcus
    Ladurner, Andreas G.
    EMBO REPORTS, 2018, 19 (10)
  • [36] Immunoexpression of Macroh2a in Uveal Melanoma
    Salvatorelli, Lucia
    Puzzo, Lidia
    Bartoloni, Giovanni
    Palmucci, Stefano
    Longo, Antonio
    Russo, Andrea
    Reibaldi, Michele
    Vinciguerra, Manlio
    Li Volti, Giovanni
    Caltabiano, Rosario
    APPLIED SCIENCES-BASEL, 2019, 9 (16):
  • [37] Multiple facets of the unique histone variant macroH2A From genomics to cell biology
    Gamble, Matthew J.
    Kraus, W. Lee
    CELL CYCLE, 2010, 9 (13) : 2568 - 2574
  • [38] Higher concentrations of histone macroH2A in the Barr body are correlated with higher nucleosome density
    Perche, PY
    Vourc'h, G
    Konecny, L
    Souchier, C
    Robert-Nicoud, M
    Dimitrov, S
    Khochbin, S
    CURRENT BIOLOGY, 2000, 10 (23) : 1531 - 1534
  • [39] Dynamic re-distribution of the histone variant macroH2A accompanying large scale chromatin remodeling in lymphocytes.
    Woodcock, CL
    Nikitina, T
    Grigoryev, SA
    Pehrson, JR
    MOLECULAR BIOLOGY OF THE CELL, 2000, 11 : 306A - 306A
  • [40] DNA CpG hypomethylation induces heterochromatin reorganization involving the histone variant macroH2A
    Ma, YH
    Jacobs, SB
    Jackson-Grusby, L
    Mastrangelo, MA
    Torres-Betancourt, JA
    Jaenisch, R
    Rasmussen, TR
    JOURNAL OF CELL SCIENCE, 2005, 118 (08) : 1607 - 1616
12345