VINYLOGOUS HYDROXAMIC ACIDS - 5-LIPOXYGENASE INHIBITORS

被引：2
|
作者：
WRIGHT, SW
PINTO, DJ
SHERK, SR
GREEN, AM
MAGOLDA, RL
机构：
[1] The Du Pont Merck Pharmaceutical Company, Du Pont Experimental Station, Wilmington
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 09期
关键词：
D O I：
10.1016/S0960-894X(00)80622-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Vinylogous hydroxamic acids were prepared as inhibitors of 5-lipoxygenase. The synthesis and preliminary SAR of these relatively unexplored compounds are described. These compounds are potent 5-lipoxygenase inhibitors which do not inhibit other enzymes of the arachidonic acid cascade.
引用
收藏
页码：1079 / 1084
页数：6
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