NEOPTERIN AS AN ENDOGENOUS ANTIOXIDANT

被引：65

作者：

KOJIMA, S ^{[1
]}

ICHO, T ^{[1
]}

KAJIWARA, Y ^{[1
]}

KUBOTA, K ^{[1
]}

机构：

[1] SCI UNIV TOKYO,BIOSCI RES INST,TOKYO 162,JAPAN

来源：

FEBS LETTERS | 1992年 / 304卷 / 2-3期

关键词：

NEOPTERIN; ANTIOXIDANT; ALLOXAN DIABETES;

D O I：

10.1016/0014-5793(92)80610-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The in vitro potency of neopterin (NP) as an antioxidant and its in vivo activity to suppress alloxan-induced diabetes were investigated. The reduced form of neopterin, 5,6,7,8-tetrahydroneopterin (NPH-4), showed an extremely high superoxide anion radical scavenging activity in two assay systems, i.e. xanthine/xanthine oxidase- and macrophage/phorbol myristate acetate (PMA)-reaction systems. NPH-4 also inhibited the oxidation of linoleic acid about as effectively as uric acid. Furthermore, NPH-4 and NP effectively suppressed alloxan-induced mouse diabetes. These results suggest that pteridines play an important role as endogenous antioxidants.

引用

页码：163 / 166

页数：4

共 19 条

[1]

ABITA JP, 1985, LANCET, V2, P51

[2] DEPENDENCE ON O-2- GENERATION BY XANTHINE-OXIDASE OF PATHOGENESIS OF INFLUENZA-VIRUS INFECTION IN MICE [J].