INCONSISTENT BACTERICIDAL ACTIVITY OF TRIPLE-COMBINATION THERAPY WITH VANCOMYCIN, AMPICILLIN, AND GENTAMICIN AGAINST VANCOMYCIN-RESISTANT, HIGHLY AMPICILLIN-RESISTANT ENTEROCOCCUS-FAECIUM

被引：33
作者：
FRAIMOW, HS
VENUTI, E
机构：
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 07期
关键词：
D O I：
10.1128/AAC.36.7.1563
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Combination therapy with ampicillin, vancomycin, and gentamicin in vitro against several clinical isolates of vancomycin-resistant, highly ampicillin-resistant Enterococcus faecium, including VanA and VanB strains, was evaluated. The MICs of ampicillin were not significantly decreased by induction with vancomycin, and the combination of ampicillin and vancomycin was not inhibitory for any strain. Triple-combination therapy was least active against highly resistant VanA isolates, achieving a reduction of less than 1 log CFU at 24 h, but demonstrated slightly more activity against VanB strains.
引用
收藏
页码：1563 / 1566
页数：4
相关论文
共 14 条
[1]   IDENTIFICATION OF VANCOMYCIN RESISTANCE PROTEIN VANA AS A D-ALANINE - D-ALANINE LIGASE OF ALTERED SUBSTRATE-SPECIFICITY [J].
BUGG, TDH ;
DUTKAMALEN, S ;
ARTHUR, M ;
COURVALIN, P ;
WALSH, CT .
BIOCHEMISTRY, 1991, 30 (08) :2017-2021
[2]   TRIPLE-COMBINATION PENICILLIN-VANCOMYCIN-GENTAMICIN FOR EXPERIMENTAL ENDOCARDITIS CAUSED BY A MODERATELY PENICILLIN-RESISTANT AND HIGHLY GLYCOPEPTIDE-RESISTANT ISOLATE OF ENTEROCOCCUS-FAECIUM [J].
CARON, F ;
CARBON, C ;
GUTMANN, L .
JOURNAL OF INFECTIOUS DISEASES, 1991, 164 (05) :888-893
[3]   INDUCIBLE CARBOXYPEPTIDASE ACTIVITY IN VANCOMYCIN-RESISTANT ENTEROCOCCI [J].
GUTMANN, L ;
BILLOTKLEIN, D ;
ALOBEID, S ;
KLARE, I ;
FRANCOUAL, S ;
COLLATZ, E ;
VANHEIJENOORT, J .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (01) :77-80
[4]  
GUTTMANN L, 1990, 30TH INT C ANT AG CH
[5]   CONCOMITANT HIGH-LEVEL VANCOMYCIN AND PENICILLIN RESISTANCE IN CLINICAL ISOLATES OF ENTEROCOCCI [J].
HANDWERGER, S ;
PERLMAN, DC ;
ALTARAC, D ;
MCAULIFFE, V .
CLINICAL INFECTIOUS DISEASES, 1992, 14 (03) :655-661
[6]   RESISTANCE TO VANCOMYCIN AND TEICOPLANIN - AN EMERGING CLINICAL PROBLEM [J].
JOHNSON, AP ;
UTTLEY, AHC ;
WOODFORD, N ;
GEORGE, RC .
CLINICAL MICROBIOLOGY REVIEWS, 1990, 3 (03) :280-291
[7]   RECOVERY OF RESISTANT ENTEROCOCCI DURING VANCOMYCIN PROPHYLAXIS [J].
KAPLAN, AH ;
GILLIGAN, PH ;
FACKLAM, RR .
JOURNAL OF CLINICAL MICROBIOLOGY, 1988, 26 (06) :1216-1218
[8]   OVERPRODUCTION OF A PENICILLIN-BINDING PROTEIN IS NOT THE ONLY MECHANISM OF PENICILLIN RESISTANCE IN ENTEROCOCCUS-FAECIUM [J].
KLARE, I ;
RODLOFF, AC ;
WAGNER, J ;
WITTE, W ;
HAKENBECK, R .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (04) :783-787
[9]  
KREISWIRTH BN, 1991, 31ST INT C ANT AG CH
[10]   EFFECTS OF COMBINATIONS OF BETA-LACTAMS, DAPTOMYCIN, GENTAMICIN, AND GLYCOPEPTIDES AGAINST GLYCOPEPTIDE-RESISTANT ENTEROCOCCI [J].
LECLERCQ, R ;
BINGEN, E ;
SU, QH ;
LAMBERTZECHOVSKI, N ;
COURVALIN, P ;
DUVAL, J .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (01) :92-98
12