SYNTHESIS OF 3-ACYL-3-ALKYLOXINDOLES

被引:22
作者
FLANN, CJ [1 ]
OVERMAN, LE [1 ]
SARKAR, AK [1 ]
机构
[1] UNIV CALIF IRVINE,DEPT CHEM,IRVINE,CA 92717
关键词
D O I
10.1016/0040-4039(91)85022-W
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Treatment of 3-(silyloxy)acrylolyl-2'(or 3')-haloanilides with LDA followed by hydrolysis gives 3-acyl-3-alkyloxindoles in preparatively useful yields.
引用
收藏
页码:6993 / 6996
页数:4
相关论文
共 19 条
[1]   INTRAMOLECULAR ALKENE ARYLATIONS FOR RAPID ASSEMBLY OF POLYCYCLIC SYSTEMS CONTAINING QUATERNARY CENTERS - A NEW SYNTHESIS OF SPIROOXINDOLES AND OTHER FUSED AND BRIDGED RING-SYSTEMS [J].
ABELMAN, MM ;
OH, T ;
OVERMAN, LE .
JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (18) :4130-4133
[2]   SYNTHESIS OF OXINDOLES BY RADICAL CYCLIZATION [J].
BOWMAN, WR ;
HEANEY, H ;
JORDAN, BM .
TETRAHEDRON LETTERS, 1988, 29 (50) :6657-6660
[3]  
Bristol JA, 1990, ANN REPORTS MED CHEM, V25
[4]   REACTION OF ETHYL 2-OXOCYCLOPENTANECARBOXYLATE WITH ARYLAMINES .1. PREPARATION OF 2,3-DIHYDRO-ALPHA-QUININDONES (2,3,4,5-TETRAHYDRO-4-OXO-1H-CYCLOPENTA[C]QUINOLINESE [J].
BROWN, RJ ;
CARVER, FWS ;
HOLLINGSWORTH, BL .
JOURNAL OF THE CHEMICAL SOCIETY, 1961, (OCT) :4295-&
[5]  
Bunnett J. F., 1973, ORG SYNTH, V5, P12
[6]   STUDIES OF RING CLOSURE VIA ARYNE INTERMEDIATEES [J].
BUNNETT, JF ;
KATO, T ;
FLYNN, RR ;
SKORCZ, JA .
JOURNAL OF ORGANIC CHEMISTRY, 1963, 28 (01) :1-&
[7]   EVIDENCE ON THE NATURE OF COBALT-MEDIATED ARYL RADICAL CYCLIZATIONS [J].
CLARK, AJ ;
JONES, K .
TETRAHEDRON LETTERS, 1989, 30 (40) :5485-5488
[8]   SYNTHESIS STUDIES DIRECTED TOWARD GELSEMINE - PREPARATION OF AN ADVANCED PENTACYCLIC INTERMEDIATE [J].
EARLEY, WG ;
OH, T ;
OVERMAN, LE .
TETRAHEDRON LETTERS, 1988, 29 (31) :3785-3788
[9]   A NEW OXINDOLE SYNTHESIS [J].
FLEMING, I ;
MOSES, RC ;
TERCEL, M ;
ZIV, J .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1991, (03) :617-626
[10]   2 NEW OXINDOLE SYNTHESES [J].
FLEMING, I ;
LORETO, MA ;
WALLACE, IHM ;
MICHAEL, JP .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1986, (02) :349-359