Spray congealing: a versatile technology for advanced drug-delivery systems

被引：25
作者：
Bertoni, Serena [1 ]
Dolci, Luisa S. [1 ]
Albertini, Beatrice [1 ]
Passerini, Nadia [1 ]
机构：
[1] Univ Bologna, Dept Pharm & Biotechnol, Via S Donato 19-2, I-40127 Bologna, Italy
来源：
THERAPEUTIC DELIVERY | 2018年 / 9卷 / 11期
关键词：
microencapsulation; multiparticulate drug-delivery systems; solid dispersion; solid lipid microparticles; solvent-free technology; spray chilling; spray cooling;
D O I：
10.4155/tde-2018-0049
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Spray congealing is a low cost, simple and versatile method to produce microparticles without the use of organic or aqueous solvent. This review provides a detailed picture of the pharmaceutical applications of this technology, with an overview of the spray-congealed-based drug-delivery systems. First, the basic principles and equipment of spray congealing technology are presented. Then, representative examples of the drug-delivery systems are examined and critically discussed. Emphasis is given on the role of formulation variables, together with practical considerations for formulation design. In addition, the current status of the industrial applications of this technology within the pharmaceutical field is examined. The final part points out benefits, limitations and future perspectives of this technology in drug delivery.
引用
收藏
页码：833 / 845
页数：14
相关论文
共 76 条
[1]   Aminolevulinic acid-loaded Witepsol microparticles manufactured using a spray congealing procedure: implications for topical photodynamic therapy [J].
Al-Kassas, Rasil ;
Donnelly, Ryan F. ;
McCarron, Paul A. .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2009, 61 (09) :1125-1135
[2]   Effect of Aerosil® on the properties of lipid controlled release microparticles [J].
Albertini, B ;
Passerini, N ;
González-Rodríguez, ML ;
Perissutti, B ;
Rodriguez, L .
JOURNAL OF CONTROLLED RELEASE, 2004, 100 (02) :233-246
[3]   Poloxamer 407 microspheres for orotransmucosal drug delivery. Part I: Formulation, manufacturing and characterization [J].
Albertini, B. ;
Passerini, N. ;
Di Sabatino, M. ;
Monti, D. ;
Burgalassi, S. ;
Chetoni, P. ;
Rodriguez, L. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 399 (1-2) :71-79
[4]   New spray congealing atomizer for the microencapsulation of highly concentrated solid and liquid substances [J].
Albertini, Beatrice ;
Passerini, Nadia ;
Pattarino, Franco ;
Rodriguez, Lorenzo .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2008, 69 (01) :348-357
[5]   Formulation of spray congealed microparticles with self-emulsifying ability for enhanced glibenclamide dissolution performance [J].
Albertini, Beatrice ;
Di Sabatino, Marcello ;
Melegari, Cecilia ;
Passerini, Nadia .
JOURNAL OF MICROENCAPSULATION, 2015, 32 (02) :181-192
[6]   Formulating SLMs as oral pulsatile system for potential delivery of melatonin to pediatric population [J].
Albertini, Beatrice ;
Di Sabatino, Marcello ;
Melegari, Cecilia ;
Passerini, Nadia .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2014, 469 (01) :67-79
[7]   Novel multifunctional platforms for potential treatment of cutaneous wounds: Development and in vitro characterization [J].
Albertini, Beatrice ;
Di Sabatino, Marcello ;
Calonghi, Natalia ;
Rodriguez, Lorenzo ;
Passerini, Nadia .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2013, 440 (02) :238-249
[8]   Evaluation of Spray Congealing as Technique for the Preparation of Highly Loaded Solid Lipid Microparticles Containing the Sunscreen Agent, Avobenzone [J].
Albertini, Beatrice ;
Mezzena, Matteo ;
Passerini, Nadia ;
Rodriguez, Lorenzo ;
Scalia, Santo .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 98 (08) :2759-2769
[9]   Polymer-lipid based mucoadhesive microspheres prepared by spray-congealing for the vaginal delivery of econazole nitrate [J].
Albertini, Beatrice ;
Passerini, Nadia ;
Di Sabatino, Marcello ;
Vitali, Beatrice ;
Brigidi, Patrizia ;
Rodriguez, Lorenzo .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 36 (4-5) :591-601
[10]   Single-dose azithromycin microsphere formulation: a novel delivery system for antibiotics [J].
Amrol, David .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2007, 2 (01) :9-12
12345678