HUMAN-LEUKOCYTE ANTIGENS IN IDIOPATHIC NEPHROTIC SYNDROME IN CHILDREN

被引：15
作者：
RUDER, H
SCHARER, K
OPELZ, G
LENHARD, V
WALDHERR, R
MULLERWIEFEL, DE
WINGEN, AM
DIPPELL, J
机构：
[1] Department of Paediatrics, University of Heidelberg, Heidelberg
[2] Department of Transplantation Immunology, University of Heidelberg, Heidelberg
[3] Department of Pathology, University of Heidelberg, Heidelberg
[4] Clementine Kinderkrankenhaus, Frankfurt
来源：
PEDIATRIC NEPHROLOGY | 1990年 / 4卷 / 05期
关键词：
NEPHROTIC SYNDROME; HUMAN LEUKOCYTE ANTIGENS; MINIMAL GLOMERULAR CHANGES; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; IMMUNOGENETICS;
D O I：
10.1007/BF00869824
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
An association of the idiopathic nephrotic syndrome (NS) with certain human leucocyte antigens (HLA) has been reported repeatedly. The aim of this study is to characterize further the clinical and histological features of patients with NS in relation to their HLA phenotypes. HLA antigens were determined in 132 paediatric patients with NS. In 91 steroid-sensitive patients (usually associated with minimal glomerular changes), the antigen frequencies of HLA-DR3, HLA-DR7, and HLA-B8, -DR3 combined were significantly increased compared with controls. The strongest association was observed with the combined occurrence of HLA-B8, -DR3, -DR7 (relative risk 21.5). This association and that with HLA-DR3 alone were strongest in the presence of frequent relapses and steroid dependence compared with children without or with infrequent relapses. The pattern of HLA antigens was similar in the 57 steroid-sensitive patients with biopsy-proven minimal glomerular changes. In 41 children with steroid-resistant NS (usually associated with focal segmental glomerulosclerosis) a similar trend for increased antigen frequencies was found but data were significant only for the combined occurrence of HLA-B8, -DR3 and -DR7. In all patients combined the frequency of the HLA associations was significantly lower when the age of onset was greater than 8 years compared with that of younger patients. It is concluded that the immunogenetic background of the steroid-sensitive and steroid-resistant NS is different and age-dependent.
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页码：478 / 481
页数：4
相关论文
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