Biogenesis, delivery, and function of extracellular RNA

被引：94

作者：

Patton, James G. ^{[1
]}

Franklin, Jeffrey L. ^{[2
,3
,4
]}

Weaver, Alissa M. ^{[2
,5
]}

Vickers, Kasey ^{[6
]}

Zhang, Bing ^{[7
]}

Coffey, Robert J. ^{[2
,3
,4
]}

Ansel, Mark ^{[8
,9
]}

Blelloch, Robert ^{[10
,11
]}

Goga, Andrei ^{[12
,13
]}

Huang, Bo ^{[14
,15
]}

L'Etoille, Noelle ^{[12
]}

Raffai, Robert L. ^{[16
,17
]}

Lai, Charles P. ^{[18
]}

Krichevsky, Anna M. ^{[19
,20
]}

Mateescu, Bogdan ^{[21
]}

Greiner, Vanille J. ^{[8
,22
]}

Hunter, Craig ^{[23
]}

Voinnet, Olivier ^{[21
]}

McManus, Michael T. ^{[22
]}

机构：

[1] Vanderbilt Univ, Dept Biol Sci, Box 1820 Stn B, Nashville, TN 37235 USA

[2] VA Med Ctr, Nashville, TN USA

[3] Vanderbilt Univ, Dept Cell & Dev Biol, Nashville, TN 37235 USA

[4] Vanderbilt Univ, Dept Med, Nashville, TN 37235 USA

[5] Vanderbilt Univ, Dept Canc Biol, Nashville, TN 37235 USA

[6] Vanderbilt Univ, Dept Cardiol, Nashville, TN 37235 USA

[7] Vanderbilt Univ, Dept Biomed Informat, Nashville, TN 37235 USA

[8] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[9] Univ Calif San Francisco, Sandler Asthma Basic Res Ctr, San Francisco, CA 94143 USA

[10] Univ Calif San Francisco, Dept Urol, San Francisco, CA USA

[11] Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA

[12] Univ Calif San Francisco, Dept Cell & Tissue Biol, San Francisco, CA 94143 USA

[13] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[14] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA USA

[15] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

[16] Univ Calif San Francisco, Dept Surg, San Francisco, CA USA

[17] VA Med Ctr, San Francisco, CA USA

[18] Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA USA

[19] Brigham & Womens Hosp, Dept Neurol, Ann Romney Ctr Neurol Dis, Boston, MA 02115 USA

[20] Harvard Univ, Sch Med, Boston, MA USA

[21] Swiss Fed Inst Technol Zurich ETH Zurich, Zurich, Switzerland

[22] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA

[23] Harvard Univ, Cambridge, MA 02138 USA

来源：

JOURNAL OF EXTRACELLULAR VESICLES | 2015年 / 4卷

基金：

美国国家卫生研究院;

关键词：

ERCC; exRNA; extracellular RNA;

D O I：

10.3402/jev.v4.27494

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Extracellular RNA (exRNA) Communication Consortium was launched by the National Institutes of Health to focus on the extent to which RNA might function in a non-cell-autonomous manner. With the availability of increasingly sensitive tools, small amounts of RNA can be detected in serum, plasma, and other bodily fluids. The exact mechanism(s) by which RNA can be secreted from cells and the mechanisms for the delivery and uptake by recipient cells remain to be determined. This review will summarize current knowledge about the biogenesis and delivery of exRNA and outline projects seeking to understand the functional impact of exRNA.

引用

页数：8

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