DISSIMILAR EFFECTS OF LITHIUM ISOTOPES ON MOTILITY IN RATS

被引：17

作者：

LIEBERMAN, KW

ALEXANDER, GJ

STOKES, P

机构：

[1] CORNELL UNIV,COLL MED,DEPT BIOCHEM,NEW YORK,NY 10021

[2] NEW YORK STATE PSYCHIAT INST,NEUTROTOXICOL RES UNIT,NEW YORK,NY 10032

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 10卷 / 06期

关键词：

Isotopes; Lithium; Lithium-6; Lithium-7; Mobility;

D O I：

10.1016/0091-3057(79)90070-4

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Male Wistar rats were injected twice daily with chlorides of pure lithium isotopes, either Li-6 or Li-7. While both salts decreased motility, the salt of Li-6 initially produced a more profound effect than the salt of Li-7. This differential effect of the isotopes proved to be time dependent and was most evident on the third day of treatment. Li-6 is likely to become a valuable tool in basic psychopharmacological research. It may possess therapeutic and/or toxic properties that are different from those of lithium salts currently used in treatment of mania. © 1979.

引用

页码：933 / 935

页数：3

共 12 条

[1]

ALEXANDER GJ, 1978, PHARMAC BIOCH BEHAV, V8, P253

[2] DISTRIBUTION AND KINETICS OF COEDTA IN SMOOTH MUSCLE AND ITS USE AS AN EXTRACELLULAR MARKER [J].