OCCURRENCE OF IMMUNOGLOBULIN G-ALKALINE PHOSPHATASE COMPLEXES IN HUMAN-SERUM

被引：30

作者：

DEBROE, ME ^{[1
]}

METS, TE ^{[1
]}

LEROUXROELS, GG ^{[1
]}

WIEME, RJ ^{[1
]}

机构：

[1] UNIV INSTELLING ANTWERPEN, DEPT INTERNAL MED, NEPHROL SECT, ANTWERPEN, BELGIUM

来源：

ANNALS OF INTERNAL MEDICINE | 1979年 / 90卷 / 01期

关键词：

D O I：

10.7326/0003-4819-90-1-30

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The authors studied three patients in whom all or part of their serum alkaline phosphatase circulated as a complex with immunoglobulin G (IgG). Serum alkaline phosphatase isozymes were visualized by their electrophoretic (in agar, agarose, and starch gel and on cellulose acetate), gel filtration, and electroimmunodiffusion behavior. The alkaline phosphatase-IgG complex was of the liver type (two cases) and bone type (one case). The reaction pattern of alkaline phosphatase with different human tissues and with sera of heterologous origin suggests that the complex is of the antigen-antibody type. A direct genetic mechanism seems unlikely since in one patient the IgG-alkaline phosphatase complex was not present in previous serum samples. The presence of this complex has no apparent correlation with the observed abnormalities. Alkaline phosphatase linked to immunoglobulin G must be considered in the interpretation of increased serum alkaline phosphatase.

引用

页码：30 / 35

页数：6

共 27 条

[21] NEWTON MA, 1967, QJ MED, V141, P17
[22] STARCH GEL ELECTROPHORESIS IN A DISCONTINUOUS SYSTEM OF BUFFERS
POULIK, MD
[J]. NATURE, 1957, 180 (4600) : 1477 - 1479
[23] DIFFERENTIAL ACTION OF NEURAMINIDASE ON HUMAN SERUM ALKALINE PHOSPHATASES
ROBINSON, JC
PIERCE, JE
[J]. NATURE, 1964, 204 (495) : 472 - &
[24] MACROMOLECULAR LACTIC-ACID DEHYDROGENASE - CAUSE OF INCREASED SERUM LACTATE-DEHYDROGENASE ACTIVITY
THOMAS, DW
ROSEN, SW
KAHN, CR
TEMPLE, R
PAPADOPO.NM
[J]. ANNALS OF INTERNAL MEDICINE, 1974, 81 (04) : 434 - 439
[25] VANBELLE H, 1977, CLIN CHEM, V23, P454
[26] WIEME RJ, 1965, AGAR GEL ELECTROPHOR
[27] GLOBULIN-BOUND AMYLASE - CAUSE OF PERSISTENTLY ELEVATED LEVELS IN SERUM
WILDING, P
COOKE, WT
NICHOLSON, GI
[J]. ANNALS OF INTERNAL MEDICINE, 1964, 60 (06) : 1053 - +

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