VIRUS-LIKE ANTIGEN ANTIBODY AND ANTIGEN-ANTIBODY COMPLEXES IN HEPATITIS MEASURED BY COMPLEMENT FIXATION

被引：367

作者：

SHULMAN, NR

BARKER, LF

机构：

[1] Clinical Hematology Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda

[2] Laboratory of Viral Immunology, Division of Biological Standards

来源：

SCIENCE | 1969年 / 165卷 / 3890期

关键词：

D O I：

10.1126/science.165.3890.304

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Complement fixation techniques are described for measuring a virus-like antigen associated with viral hepatitis. Antigen was found in the blood of 98 percent of 130 patients, with the serum form of hepatitis, from whom multiple samples were obtained. Antibodies arising during hepatitis are usually combined with antigen and cause anticomplementary activity in the serum, which is reversible with excess antigen or antibody. Tests for antigen and specific anticomplementary activity can be used diagnostically and to screen blood donors for hepatitis carriers.

引用

页码：304 / &

共 14 条

[1]

ALLISON AC, 1961, LANCET, V1, P634

[2]

BAKER L, IN PRESS

[3]

BARKER LF, 1969, J IMMUNOL, V102, P1529

[4] PARTICLES ASSOCIATED WITH AUSTRALIA ANTIGEN IN SERA OF PATIENTS WITH LEUKAEMIA DOWNS SYNDROME AND HEPATITIS [J].