BRAIN-DERIVED NEUROTROPHIC FACTOR PRETREATMENT EXERTS A PARTIALLY PROTECTIVE EFFECT AGAINST GLUTAMATE-INDUCED NEUROTOXICITY IN CULTURED RAT CORTICAL-NEURONS

被引：54
作者：
SHIMOHAMA, S
TAMURA, Y
AKAIKE, A
TSUKAHARA, T
OHARA, O
WATANABE, S
KIMURA, J
机构：
[1] FUKUYAMA UNIV,FAC PHARM & PHARMACEUT SCI,DEPT NEUROPHARMACOL,FUKUYAMA,HIROSHIMA 72902,JAPAN
[2] NATL CARDIOVASC CTR,DEPT CEREBROVASC SURG,OSAKA,OSAKA 565,JAPAN
[3] SHIONOGI & CO LTD,SHIONOGI RES LABS,OSAKA,OSAKA 553,JAPAN
来源：
NEUROSCIENCE LETTERS | 1993年 / 164卷 / 1-2期
关键词：
RECOMBINANT BRAIN-DERIVED NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR; GLUTAMATE; NEUROTOXICITY; CULTURE; CORTEX; PROTECTION;
D O I：
10.1016/0304-3940(93)90856-G
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of recombinant brain-derived neurotrophic factor (BDNF) on cultured rat cortical neurons was examined. Brief exposure of cortical neurons to glutamate followed by incubation with glutamate-free medium reduced cell viability by 60-70% when compared with the control value. Simultaneous addition of recombinant BDNF to rat cortical cultures with glutamate did not affect this reduction of cell viability. However, 24 h pretreatment of rat cortical cultures with recombinant BDNF resulted in a significant reduction of glutamate-induced neuronal damage. These findings suggest that BDNF can protect cortical neurons against glutamate-induced neurotoxicity.
引用
收藏
页码：55 / 58
页数：4
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