ACTIVIN SIGNALING AND RESPONSE TO A MORPHOGEN GRADIENT

被引：309

作者：

GURDON, JB ^{[1
]}

HARGER, P ^{[1
]}

MITCHELL, A ^{[1
]}

LEMAIRE, P ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT ZOOL,CAMBRIDGE CB2 3EJ,ENGLAND

来源：

NATURE | 1994年 / 371卷 / 6497期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/371487a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Using combinations of amphibian embryo tissues, it is shown that the selection of genes expressed by a cell is determined by its distance from a source of activin, a peptide growth factor contained in vegetal cells and able to induce other cells to form mesoderm. This long-range signal spreads over at least 10 cell diameters In a few hours. It does so by passive diffusion, because It can by-pass cells that do not themselves respond to the signal nor synthesize protein. These results provide direct support for the operation of a morphogen concentration gradient In vertebrate development.

引用

页码：487 / 492

页数：6

共 47 条

[41] ACTIVINS ARE EXPRESSED EARLY IN XENOPUS EMBRYOGENESIS AND CAN INDUCE AXIAL MESODERM AND ANTERIOR STRUCTURES [J].