SERUM HOUSE-DUST-MITE ANTIBODIES AND REDUCED FEV(1) IN ADULTS OF A NORWEGIAN COMMUNITY

被引：26

作者：

OMENAAS, E ^{[1
]}

BAKKE, P ^{[1
]}

EIDE, GE ^{[1
]}

ELSAYED, S ^{[1
]}

GULSVIK, A ^{[1
]}

机构：

[1] UNIV BERGEN, DEPT BIOL CLIN, DIV BIOCHEM, ALLERGY RES GRP, BERGEN, NORWAY

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 1995年 / 152卷 / 04期

关键词：

D O I：

10.1164/ajrccm.152.4.7551364

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

In this cross-sectional study we investigated whether the presence of specific serum IgE antibodies to house dust mite, timothy, bitch, cat, and mold was associated with a reduced FEV(1) in adults. We performed complete examinations on 82% of a stratified random sample of 18 to 73-yr-old adults (n = 1,239). Subjects with house-dust-mite antibodies had lower (p = 0.002) sex, age, and height standardized residuals of FEV(1) (SFEV(1)) than those without any specific IgE antibody. This relationship did not differ significantly by sex, age, smoking habit, total serum IgE level, or season, and remained significant after excluding subjects with obstructive lung disease. For house-dust-mite antibodies we also observed a dose-response relationship between antibody levels and impaired lung function. In a final multiple linear regression analysis the presence of house-dust-mite antibodies was the only significant predictor (regression coefficient: -0.425; SE = 0.189; p = 0.02) of reduced SFEV(1) after adjusting for smoking habit and lifetime tobacco consumption, season, total serum IgE level, and respiratory-symptom and disease status. Thus, house-dust-mite allergy is an independent predictor of reduced lung function in adults of a wide age range.

引用

页码：1158 / 1163

页数：6

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