EFFECT OF SUBACUTE TOLUENE ADMINISTRATION ON THE ENKEPHALINERGIC NEUROMODULATORY SYSTEM IN RATS AND PROTECTIVE ACTION OF GANGLIOSIDE TREATMENTS

被引：3
作者：
DEGANDARIAS, JM [1 ]
ECHEVARRIA, E [1 ]
SERRANO, R [1 ]
IRAZUSTA, J [1 ]
CASIS, L [1 ]
机构：
[1] UNIV BASQUE COUNTRY,SCH MED,DEPT PHYSIOL,BILBAO,SPAIN
来源：
TOXICOLOGY AND INDUSTRIAL HEALTH | 1994年 / 10卷 / 03期
关键词：
TOLUENE; ENKEPHALIN; GANGLIOSIDES;
D O I：
10.1177/074823379401000305
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Gangliosides perform protective functions in the central nervous system. This paper describes a study of the effect of ganglioside administration on toluene neurotoxicity. Rat brain met-enkephalin immunostaining in the central amygdaloid nuclei showed changes in rats treated simultaneously with gangliosides and toluene with respect to rats treated with toluene alone. It is suggested that gangliosides prevent toluene neurotoxicity at this level, leading to hypothetical neurobehavioral changes.
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页码：155 / 161
页数：7
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