THE INFLUENCE OF MUSCARINIC AND PROSTAGLANDIC MECHANISMS ON REGIONAL CEREBRAL AND PERIPHERAL-BLOOD FLOWS AND ON THE VASCULAR EFFECTS OF THYROTROPIN-RELEASING-HORMONE (TRH)

被引：4
作者：
KOSKINEN, LOD
机构：
[1] UPPSALA UNIV, CTR BIOMED, DEPT PHYSIOL & MED BIOPHYS, UPPSALA, SWEDEN
[2] UMEA UNIV HOSP, DEPT NEUROSURG, UMEA, SWEDEN
来源：
ACTA PHYSIOLOGICA SCANDINAVICA | 1994年 / 152卷 / 04期
关键词：
AUTONOMIC NERVOUS SYSTEM; CARDIOVASCULAR FUNCTION; CHOLINERGIC MECHANISMS; PEPTIDES; PROSTAGLANDINS; REGIONAL BLOOD FLOW; THYROTROPIN RELEASING HORMONE; TRH;
D O I：
10.1111/j.1748-1716.1994.tb09822.x
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
TRH has pronounced vascular effects. The final transmitter mechanisms of these effects are not fully understood. The present study was conducted in order to elucidate whether these effects are mediated by prostaglandic or muscarinic mechanisms. Muscarinic blockade augmented the vasoconstricting- and presser effect of TRH; vasodilation in the brain was attenuated only in the caudate nucleus. Indomethacin provoked a decrease in regional cerebral blood flow and in the gastric mucosal blood flow. No effect of indomethacin was observed on the Vascular effects of TRH. Tt is concluded that the cerebral vasodilating and peripheral vasoconstricting effects of TRH are not mediated by prostaglandins. Muscarinic mechanisms are involved in the vasodilating effect of TRH only in the caudate nucleus.
引用
收藏
页码：399 / 406
页数：8
相关论文
共 41 条
[31]  
NURMINEN ML, 1985, ACTA PHYSIOL SCAND, V124, P421
[32]   CARDIOVASCULAR EFFECT OF INTRAVENOUSLY ADMINISTERED THYROTROPIN-RELEASING-HORMONE AND ITS CONCENTRATION IN PUSH-PULL PERFUSION OF THE 4TH VENTRICLE IN CONSCIOUS AND PENTOBARBITAL-ANESTHETIZED RATS [J].
OKUDA, C ;
TANAKA, H ;
MIYAZAKI, M .
LIFE SCIENCES, 1988, 42 (11) :1181-1188
[33]   EFFECTS OF THYROTROPIN-RELEASING-HORMONE ON REGIONAL CEREBRAL BLOOD-FLOW IN MAN [J].
OTURAI, PS ;
FRIBERG, L ;
SAM, I ;
PERRILD, H .
ACTA ENDOCRINOLOGICA, 1992, 126 (03) :243-246
[34]  
REIS DJ, 1982, CEREBRAL BLOOD FLOW, P475
[35]   STIMULATION OF THE ROSTRAL VENTROLATERAL MEDULLARY NEURONS INCREASES CORTICAL CEREBRAL BLOOD-FLOW VIA ACTIVATION OF THE INTRACEREBRAL NEURAL PATHWAY [J].
SAEKI, Y ;
SATO, A ;
SATO, Y ;
TRZEBSKI, A .
NEUROSCIENCE LETTERS, 1989, 107 (1-3) :26-32
[36]   EFFECTS OF NG-NITRO-L-ARGININE METHYL-ESTER ON THE CARDIOVASCULAR-SYSTEM OF THE ANESTHETIZED RABBIT AND ON THE CARDIOVASCULAR-RESPONSE TO THYROTROPIN-RELEASING-HORMONE [J].
SELIGSOHN, EE ;
BILL, A .
BRITISH JOURNAL OF PHARMACOLOGY, 1993, 109 (04) :1219-1225
[37]   EFFECTS OF ALPHA2-ADRENOCEPTOR BLOCKADE AND THYROTROPIN-RELEASING-HORMONE (TRH) ON THE CARDIOVASCULAR-SYSTEM IN THE RABBIT [J].
SELIGSOHN, EE ;
KOSKINEN, LOD .
ACTA PHYSIOLOGICA SCANDINAVICA, 1991, 143 (02) :187-194
[38]   ADRENERGIC AND NONADRENERGIC CARDIOVASCULAR EFFECTS OF THYROTROPIN-RELEASING-HORMONE (TRH) IN THE ANESTHETIZED RABBIT [J].
SELIGSOHN, EE .
ACTA PHYSIOLOGICA SCANDINAVICA, 1992, 146 (01) :107-117
[39]  
SELIGSOHN EE, 1992, NEUORPEPTIDES, V22, pP61
[40]   HEMODYNAMIC AND NEURAL MECHANISMS OF ACTION OF THYROTROPIN-RELEASING-HORMONE IN THE RAT [J].
SIREN, AL ;
LAKE, CR ;
FEUERSTEIN, G .
CIRCULATION RESEARCH, 1988, 62 (01) :139-154
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