EFFECT OF DEXTRAN ON PREDAMAGED CORNEAL ENDOTHELIUM - AN ORGAN-CULTURE STUDY

被引：10
|
作者：
LIN, CP
BOHNKE, M
DRAEGER, J
机构：
[1] UNIV BERN,INSELSPITAL,DEPT OPHTHALMOL,CH-3010 BERN,SWITZERLAND
[2] UNIV HAMBURG,EYE CLIN,W-2000 HAMBURG 13,GERMANY
来源：
OPHTHALMIC RESEARCH | 1992年 / 24卷 / 03期
关键词：
CORNEAL ENDOTHELIUM; ORGAN CULTURE; DEXTRAN; CORNEAL ENDOTHELIAL REGENERATION;
D O I：
10.1159/000267157
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Dextran T500 was used as a supplement in organ culture medium to evaluate its effect on corneal endothelium with disseminated damage. After 1 week of culturing, the control group showed an intact endothelium throughout the entire cornea. However, in the dextran-supplemented group, multiple endothelial necroses were observed in 5 of 10 corneas. Besides, intracytoplasmic vacuoles and granules, deposits on the endothelial surface and widened intercellular spaces were quite numerous. The potential toxicity of dextran to degenerated corneal endothelial cells may be responsible for these findings.
引用
收藏
页码：125 / 128
页数：4
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