NUCLEOTIDE-SEQUENCE OF THE GENES ENCODING THE MATRIX PROTEIN OF 2 WILD-TYPE MEASLES-VIRUS STRAINS

被引:20
作者
BACZKO, K
BRINCKMANN, U
PARDOWITZ, I
RIMA, BK
TERMEULEN, V
机构
[1] QUEENS UNIV BELFAST,DIV GENET ENGN,BELFAST BT9 7BL,ANTRIM,NORTH IRELAND
[2] MAX PLANCK INST EXPTL MED,W-3400 GOTTINGEN,GERMANY
基金
英国惠康基金;
关键词
D O I
10.1099/0022-1317-72-9-2279
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The nucleotide sequences of the matrix protein (M) genes of two wild-type measles virus (MV) isolates (JM and CM) have been determined and shown to differ in 56 positions; 31 of these differences are located in the non-coding region and 25 in the coding region of the gene. Most (80%) of the mutations in the coding region are changes to the third base of a codon. A maximum parsimony analysis of the available M gene nucleotide sequences allowed the construction of a tree with at least three lineages or subtypes. One wild-type strain (JM) was very similar to a subacute sclerosing panencephalitis virus strain (case B); the second wild-type strain, CM, showed nucleotide sequence similarity with MV from a case of measles inclusion body encephalitis. Both wild-type virus sequences are distinct from those so far determined for vaccine strains.
引用
收藏
页码:2279 / 2282
页数:4
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