ENHANCED EXTRACELLULAR DOPAMINE LEVEL MAY BE THE FUNDAMENTAL NEUROPHARMACOLOGICAL BASIS OF CROSS-BEHAVIORAL SENSITIZATION BETWEEN METHAMPHETAMINE AND COCAINE - AN INVIVO DIALYSIS STUDY IN FREELY MOVING RATS

被引：110

作者：

AKIMOTO, K ^{[1
]}

HAMAMURA, T ^{[1
]}

KAZAHAYA, Y ^{[1
]}

AKIYAMA, K ^{[1
]}

OTSUKI, S ^{[1
]}

机构：

[1] OKAYAMA UNIV,SCH MED,DEPT NEUROPSYCHIAT,OKAYAMA 700,JAPAN

来源：

BRAIN RESEARCH | 1990年 / 507卷 / 02期

关键词：

Cocaine; Cross-sensitization; Intracerebral dialysis; Methamphetamine;

D O I：

10.1016/0006-8993(90)90295-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intracerebral dialysis was used to study the mechanism underlying cross-behavioral sensitization between methamphetamine (MAP) and cocaine. The challenge injection of cocaine caused a significantly greater increase in striatal perfusate dopamine (DA) levels in MAP-pretreated rats than in saline-pretreated rats. Similarly, the challenge injection of MAP caused a significantly greater increased in extracellular DA levels in cocaine-pretreated rats than in control rats. These results suggest that an enhancement in striatal DA efflux may play an important role in cross-behavioral sensitization between MAP and cocaine. © 1990.

引用

页码：344 / 346

页数：3

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