NOREPINEPHRINE INVOLVEMENT IN PENILE DETUMESCENCE

被引：48

作者：

DIEDERICHS, W ^{[1
]}

STIEF, CG ^{[1
]}

LUE, TF ^{[1
]}

TANAGHO, EA ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT UROL,SAN FRANCISCO,CA 94143

来源：

JOURNAL OF UROLOGY | 1990年 / 143卷 / 06期

关键词：

D O I：

10.1016/S0022-5347(17)40251-5

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Adrenergic neurotransmission was studied in dogs. Blood samples for catecholamine assay were collected from the flaccid penis, the erect penis after cavernous nerve stimulation and during detumescence induced by sympathetic trunk stimulation. Epinephrine concentration was not significantly different in these three stages. However, norepinephrine concentration increased significantly (p < 0.005) during induced detumescence from 505 ± 311 [pg./ml.] to 747 ± 489 [pg./ml.]. Intracavernous application of norepinephrine abolished cavernous nerve induced erection in a dose dependent manner. Sympathetic trunk stimulation reduced or abolished erection induced by acetylcholine or by vasoactive intestinal polypeptide. We conclude that norepinephrine is an important neurotransmitter in the control of penile detumescence.

引用

页码：1264 / 1266

页数：3

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