MEDIATION OF CARDIOPROTECTION BY TRANSFORMING GROWTH-FACTOR-BETA

被引：295

作者：

LEFER, AM ^{[1
]}

TSAO, P ^{[1
]}

AOKI, N ^{[1
]}

PALLADINO, MA ^{[1
]}

机构：

[1] GENENTECH INC, DEPT IMMUNOL RES & ASSAY TECHNOL, S SAN FRANCISCO, CA 94080 USA

来源：

SCIENCE | 1990年 / 249卷 / 4964期

关键词：

D O I：

10.1126/science.2164258

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Myocardial ischemia causes heart injury that is characterized by an increase in circulating tumor necrosis factor (TNF), the local production of superoxide anions, the loss of coronary vasodilation (relaxation) in response to agents that release endothelial cell relaxation factor, and cardiac tissue damage. Ischemic injury can be mimicked by TNF. When given before or immediately after ischemic injury, transforming growth factor-β (TGF-β) reduced the amount of superoxide anions in the coronary circulation, maintained endothelial-dependent coronary relaxation, and reduced injury mediated by exogenous TNF. Thus, TGF-β prevented severe cardiac injury, perhaps by alleviating damage mediated by increases in circulating TNF.

引用

页码：61 / 64

页数：4

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