BRAF mutant colorectal cancer as a distinct subset of colorectal cancer: clinical characteristics, clinical behavior, and response to targeted therapies
被引:170
作者:
Clarke, Callisia N.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA
Clarke, Callisia N.
[1
]
Kopetz, E. Scott
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA
Kopetz, E. Scott
[2
]
机构:
[1] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX 77030 USA
Colorectal cancer (CRC);
BRAF;
prognostic biomarker;
targeted therapy;
D O I:
10.3978/j.issn.2078-6891.2015.077
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Despite new and more effective cytotoxic chemotherapy, limitations to conventional agents have been reached in a subset of patients with advanced colorectal cancer (CRC). The identification of novel prognostic and predictive biomarkers to guide individualized treatment plans is critical to overcoming therapeutic resistance. Mutation of the BRAF proto-oncogene is linked to a variety of cancers and is increasingly being used as a prognostic tool and therapeutic target. This paper is a comprehensive review of the literature that summarizes the clinical, pathologic, and molecular features of BRAF mutated CRC that support the hypothesis that BRAF mutant cancers represent a distinct subset of CRC with its own clinical implications with regard to prognosis, treatments and emerging therapeutic strategies.
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Weisenberger, Daniel J.
D Siegmund, Kimberly
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
D Siegmund, Kimberly
Campan, Mihaela
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Campan, Mihaela
Young, Joanne
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Young, Joanne
Long, Tiffany I.
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Long, Tiffany I.
Faasse, Mark A.
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Faasse, Mark A.
Kang, Gyeong Hoon
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Kang, Gyeong Hoon
Widschwendter, Martin
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Widschwendter, Martin
Weener, Deborah
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Weener, Deborah
Buchanan, Daniel
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Buchanan, Daniel
Koh, Hoey
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Koh, Hoey
Simms, Lisa
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Simms, Lisa
Barker, Melissa
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Barker, Melissa
Leggett, Barbara
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Leggett, Barbara
Levine, Joan
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Levine, Joan
Kim, Myungjin
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Kim, Myungjin
French, Amy J.
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
French, Amy J.
Thibodeau, Stephen N.
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Thibodeau, Stephen N.
Jass, Jeremy
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Jass, Jeremy
Haile, Robert
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Haile, Robert
Laird, Peter W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USAUniv So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Yaeger, Rona
Cercek, Andrea
论文数: 0引用数: 0
h-index: 0
机构:Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Cercek, Andrea
Chou, Joanne F.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Epidemiol Biostat, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Chou, Joanne F.
Sylvester, Brooke E.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Sylvester, Brooke E.
Kemeny, Nancy E.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Kemeny, Nancy E.
Hechtman, Jaclyn F.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Hechtman, Jaclyn F.
Ladanyi, Marc
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Ladanyi, Marc
Rosen, Neal
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Rosen, Neal
Weiser, Martin R.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Weiser, Martin R.
Capanu, Marinela
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Epidemiol Biostat, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Capanu, Marinela
Solit, David B.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Solit, David B.
D'Angelica, Michael I.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
D'Angelica, Michael I.
Vakiani, Efsevia
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Vakiani, Efsevia
Saltz, Leonard B.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Weisenberger, Daniel J.
D Siegmund, Kimberly
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
D Siegmund, Kimberly
Campan, Mihaela
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Campan, Mihaela
Young, Joanne
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Young, Joanne
Long, Tiffany I.
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Long, Tiffany I.
Faasse, Mark A.
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Faasse, Mark A.
Kang, Gyeong Hoon
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Kang, Gyeong Hoon
Widschwendter, Martin
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Widschwendter, Martin
Weener, Deborah
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Weener, Deborah
Buchanan, Daniel
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Buchanan, Daniel
Koh, Hoey
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Koh, Hoey
Simms, Lisa
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Simms, Lisa
Barker, Melissa
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Barker, Melissa
Leggett, Barbara
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Leggett, Barbara
Levine, Joan
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Levine, Joan
Kim, Myungjin
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Kim, Myungjin
French, Amy J.
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
French, Amy J.
Thibodeau, Stephen N.
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Thibodeau, Stephen N.
Jass, Jeremy
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Jass, Jeremy
Haile, Robert
论文数: 0引用数: 0
h-index: 0
机构:Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
Haile, Robert
Laird, Peter W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USAUniv So Calif, Dept Surg, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Yaeger, Rona
Cercek, Andrea
论文数: 0引用数: 0
h-index: 0
机构:Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Cercek, Andrea
Chou, Joanne F.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Epidemiol Biostat, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Chou, Joanne F.
Sylvester, Brooke E.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Sylvester, Brooke E.
Kemeny, Nancy E.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Kemeny, Nancy E.
Hechtman, Jaclyn F.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Hechtman, Jaclyn F.
Ladanyi, Marc
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Ladanyi, Marc
Rosen, Neal
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Rosen, Neal
Weiser, Martin R.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Weiser, Martin R.
Capanu, Marinela
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Epidemiol Biostat, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Capanu, Marinela
Solit, David B.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Solit, David B.
D'Angelica, Michael I.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
D'Angelica, Michael I.
Vakiani, Efsevia
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Vakiani, Efsevia
Saltz, Leonard B.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA