TENDINOPATHY AND TENDON RUPTURE ASSOCIATED WITH STATINS

被引：21
作者：
Deren, Matthew E. [1 ]
Klinge, Stephen A. [1 ]
Mukand, Nita H. [2 ,3 ]
Mukand, Jon A. [1 ,3 ,4 ]
机构：
[1] Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Dept Orthopaed Surg, Providence, RI 02903 USA
[2] Wesleyan Univ, Middletown, CT USA
[3] Southern New England Rehabil Ctr, North Providence, RI 02904 USA
[4] Tufts Univ, Sch Med, Medford, MA 02155 USA
来源：
JBJS REVIEWS | 2016年 / 4卷 / 05期
关键词：
D O I：
10.2106/JBJS.RVW.15.00072
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Use of statins may be associated with certain tendinopathies and tendon ruptures, especially of the Achilles, quadriceps, and distal biceps tendons. Tendinopathy usually occurs within the first year of statin use and improves after the drug therapy is stopped. Systemic conditions with a higher risk of tendon rupture include diabetes, gout, rheumatoid arthritis, and chronic kidney disease. Certain drugs, such as corticosteroids and fluoroquinolones, have also been implicated in tendon ruptures. Patients with these systemic conditions who are taking statins in combination with other drugs that increase the risk of tendon injury should be educated about this risk and alternative treatments, including diet and exercise.
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