STUDIES ON THE CHEMISTRY OF THIENOANELLATED O,N-CONTAINING AND S,N-CONTAINING HETEROCYCLES .6. SYNTHESIS OF SOME THIENOANELLATED [1,4]BENZOXAZEPINES

Substituted thieno[2,3-b][1,4]benzoxazepine derivatives as well as thieno[3,2-b][1,4]benzoxazepine derivatives have been synthesized. They are thienoanalogues of loxapine, a potent antipsychotic drug. Research activities concentrate on the preparation of structurally modified compounds of loxapine to minimize its undesirable extrapyramidal symptoms.