GLUCURONIDATION OF THYROID-HORMONE BY HUMAN BILIRUBIN AND PHENOL UDP-GLUCURONOSYLTRANSFERASE ISOENZYMES

被引：53
|
作者：
VISSER, TJ [1 ]
KAPTEIN, E [1 ]
GIJZEL, AL [1 ]
DEHERDER, WW [1 ]
EBNER, T [1 ]
BURCHELL, B [1 ]
机构：
[1] UNIV DUNDEE,DEPT BIOCHEM MED,DUNDEE DD1 4HN,SCOTLAND
来源：
FEBS LETTERS | 1993年 / 324卷 / 03期
基金：
英国惠康基金;
关键词：
THYROID HORMONE; IODOTHYRONINE; GLUCURONIDATION; BILIRUBIN; PHENOL; UDP-GLUCURONOSYLTRANSFERASE; HUMAN LIVER;
D O I：
10.1016/0014-5793(93)80151-J
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The glucuronidation of thyroid hormone by UDP-glucuronyltransferases (UGTs) stably transfected in Chinese hamster V79 lung fibroblasts was investigated. Human bilirubin UGT (HP3) and phenol UGT (HP4) both catalysed the glucuronidation of T4 and rT3, whereas glucuronidation of T3 was not significant. rT3 was the preferred substrate for both isoenzymes, glucuronidation rates being 1.6- and 6.4-times higher than conjugation of T4 by HP3 and HP4 clones, respectively. This is the first identification of thyroid hormone as potential alternative endogenous substrate for bilirubin UGT.
引用
收藏
页码：358 / 360
页数：3
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