ADRENAL-FUNCTION IN ASTHMATIC-CHILDREN TREATED WITH INHALED BUDESONIDE

被引：23
作者：
BISGAARD, H
PEDERSEN, S
NIELSEN, MD
OSTERBALLE, O
机构：
[1] CTY HOSP KOLDING,DEPT PAEDIAT,KOLDING,DENMARK
[2] UNIV COPENHAGEN HOSP,DEPT CLIN PHYSIOL,DK-2100 COPENHAGEN,DENMARK
[3] CTY HOSP VIBORG,DEPT PAEDIAT,VIBORG,DENMARK
来源：
ACTA PAEDIATRICA SCANDINAVICA | 1991年 / 80卷 / 02期
关键词：
BUDESONIDE; ADRENAL FUNCTION; SYSTEMIC ACTIVITY; BRONCHIAL ASTHMA; CHILDREN;
D O I：
10.1111/j.1651-2227.1991.tb11836.x
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The effect of the inhaled topical steroid budesonide on adrenal function was evaluated in 33 children (aged 7-15 years) with moderate bronchial asthma. The trial was designed as a prospective single-blind study of the effect of budesonide in daily doses of 200-mu-g through 400-mu-g to 800-mu-g in three randomized consecutive periods of 8 weeks. The unstimulated diurnal production of cortisol was assessed by measurement of free cortisol in 24-hour urine samples at the end of each period. No significant dose-related suppression was found. The cortisol production did not differ significantly during treatment with 800-mu-g budesonide as compared to treatment with 200-mu-g budesonide (95% confidence interval: 74%-112%). It is concluded, that budesonide is a topical steroid with a favourable ratio between topical and systemic effects in asthmatic children.
引用
收藏
页码：213 / 217
页数：5
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