HEMODYNAMIC AND HORMONAL EFFECTS OF SHORT-TERM ESTRADIOL TREATMENT IN POST-MENOPAUSAL WOMEN

被引：20

作者：

LUOTOLA, H

PYORALA, T

LAHTEENMAKI, P

TOIVANEN, J

机构：

[1] CENT FINLAND CENT HOSP, DEPT OBSTET & GYNECOL, SF-40620 JYVASKYLA, FINLAND

[2] CENT FINLAND CENT HOSP, ISOTOPE LAB, JYVASKYLA, FINLAND

[3] UNIV HELSINKI, CENT HOSP, DEPT OBSTET & GYNECOL 2, SF-00170 HELSINKI 17, FINLAND

[4] UNIV HELSINKI, DEPT MED CHEM, RES LAB, SF-00170 HELSINKI 17, FINLAND

来源：

MATURITAS | 1979年 / 1卷 / 04期

关键词：

Blood pressure; Central haemodynamics; Menopause; Oestrogen substitution;

D O I：

10.1016/0378-5122(79)90019-7

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Haemodynamic changes during a 3-wk treatment with oestradiol valerianate (2 mg/day orally) were studied in 12 postmenopausal women by isotope 113Inm radiocardiography. Systolic blood pressure measured in the supine position decreased during oestradiol treatment by 3% (P < 0.05) and the diastolic blood pressure decreased by 4% (P < 0.01). The heart rate decreased by 15% (P < 0.001). Blood volume increased during oestrogen treatment by 5% (P < 0.05) whereas cardiac output decreased by 9% (P < 0.05). Stroke volume increased by 13% (P < 0.001) due to concomitant decrease in heart rate. Changes in plasma oestrone and oestradiol concentrations during oestradiol valerianate substitution showed a positive correlation with the changes of blood volume. © 1979.

引用

页码：287 / 294

页数：8

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