SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF PHENOL-2,6-PYRIDINEDIAMIDE COMPLEXES WITH Fe(III) AND Mo(VI)

The paper is focused on the synthesis and characterization of a new ligand (amide-phenolate) N2,N6-bis(4-hydroxyphenyl)pyridine-2,6-dicarboxamide, L, that may be used as biomimetic analogue of Fe(III) or Mo(VI)-siderophores. Complex compounds of this ligand with Fe(III) or Mo(VI) have been obtained for a metal-ligand molar ratio of 1:1 and 2:1. The general proposed formulae [MoO2(OH2)2(L)]Cl2 center dot 2H2O, [Fe(OH2)3(L)](ClO4)3, [MoO2(L)2]Cl2 center dot 2CH3CN, [Fe(L)2](ClO4)3 center dot 2H2O were supported by elemental chemical analysis, electronic and vibrational spectra, NMR spectra. The newly synthesised compounds possess antibacterial and antifungal activity against Staphylococcus aureus (as gram positive bacteria), Pseudomonas aeruginosa, Escherichia coli and Proteus mirabilis, (as gram negative bacteria) and Candida albicans as fungi species, [Fe(OH2)3(L)](ClO4)3 complex showing effects comparable to Kanamycin, Tetracycline and Amoxicillin.