CPG ISLANDS AND GENES

被引：401
作者：
CROSS, SH
BIRD, AP
机构：
[1] Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh, EH9 3JR Scotland, King's Buildings
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 03期
关键词：
D O I：
10.1016/0959-437X(95)80044-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Of the estimated 45 000 CpG islands in the human genome, the overwhelming majority are found at the 5' ends of genes and their identification and cloning are proving very useful for finding and isolating genes. Recent work has shed light on the chromosomal distribution and origin of CpG islands. It has been shown unequivocally that CpG islands are concentrated in the R band chromosomal regions and that intact transcription factor binding sites are required for their maintenance. Cases of methylation of CpG islands and inactivation of the associated genes have been reported which may be important in ageing, tumorigenesis and imprinting.
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页码：309 / 314
页数：6
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