This is an unusual and interesting case report concerning a 10 year old boy with an initial diagnosis of Ewing's sarcoma of the right tibia. He was successfully treated with a chemotherapy regimen consisting of vincristine, cyclophosphamide (cumulative dose 7200 mg/m(2)), doxorubicin, etoposide (cumulative dose 2700 mg/m(2)) and cisplatin and local radiotherapy to the tibia. After an interval of 37 months he developed CALLA positive acute lymphoblastic leukemia with 11q23 chromosomal abnormality. The possible roles of etoposide and cyclophosphamide are discussed.
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Univ Pittsburgh, Inst Canc, Div Hematol Oncol, Pittsburgh, PA 15232 USA
Univ Pittsburgh, Sch Med, Pittsburgh, PA 15232 USAUniv Pittsburgh, Inst Canc, Div Hematol Oncol, Pittsburgh, PA 15232 USA
McHayleh, Wassim
Sehgal, Rajesh
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Univ Pittsburgh, Inst Canc, Div Hematol Oncol, Pittsburgh, PA 15232 USA
Univ Pittsburgh, Sch Med, Pittsburgh, PA 15232 USAUniv Pittsburgh, Inst Canc, Div Hematol Oncol, Pittsburgh, PA 15232 USA
Sehgal, Rajesh
Redner, Robert L.
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Univ Pittsburgh, Inst Canc, Div Hematol Oncol, Pittsburgh, PA 15232 USA
Univ Pittsburgh, Sch Med, Pittsburgh, PA 15232 USAUniv Pittsburgh, Inst Canc, Div Hematol Oncol, Pittsburgh, PA 15232 USA
Redner, Robert L.
Raptis, Anastasios
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Univ Pittsburgh, Inst Canc, Div Hematol Oncol, Pittsburgh, PA 15232 USA
Univ Pittsburgh, Sch Med, Pittsburgh, PA 15232 USAUniv Pittsburgh, Inst Canc, Div Hematol Oncol, Pittsburgh, PA 15232 USA
Raptis, Anastasios
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Agha, Mounzer
Natale, James
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Univ Pittsburgh, Inst Canc, Div Hematol Oncol, Pittsburgh, PA 15232 USA
Univ Pittsburgh, Sch Pharm, Pittsburgh, PA 15232 USAUniv Pittsburgh, Inst Canc, Div Hematol Oncol, Pittsburgh, PA 15232 USA
Natale, James
Luong, The Minh
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Univ Pittsburgh, Sch Pharm, Pittsburgh, PA 15232 USA
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15232 USAUniv Pittsburgh, Inst Canc, Div Hematol Oncol, Pittsburgh, PA 15232 USA
Luong, The Minh
Schlesselman, James J.
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Univ Pittsburgh, Sch Pharm, Pittsburgh, PA 15232 USA
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15232 USAUniv Pittsburgh, Inst Canc, Div Hematol Oncol, Pittsburgh, PA 15232 USA
Schlesselman, James J.
Foon, Kennteh A.
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Univ Pittsburgh, Inst Canc, Div Hematol Oncol, Pittsburgh, PA 15232 USA
Univ Pittsburgh, Sch Med, Pittsburgh, PA 15232 USAUniv Pittsburgh, Inst Canc, Div Hematol Oncol, Pittsburgh, PA 15232 USA
Foon, Kennteh A.
Boyiadzis, Michael
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Univ Pittsburgh, Inst Canc, Div Hematol Oncol, Pittsburgh, PA 15232 USA
Univ Pittsburgh, Sch Med, Pittsburgh, PA 15232 USAUniv Pittsburgh, Inst Canc, Div Hematol Oncol, Pittsburgh, PA 15232 USA