EXPRESSION AND LOCALIZATION OF HEPATOCYTE GROWTH-FACTOR IN RAT SUBMANDIBULAR-GLAND

被引：34
作者：
AMANO, O
MATSUMOTO, K
NAKAMURA, T
ISEKI, S
机构：
[1] KANAZAWA UNIV,SCH MED,DEPT ANAT,KANAZAWA 920,JAPAN
[2] OSAKA UNIV,SCH MED,BIOMED RES CTR,DIV BIOCHEM,SUITA,OSAKA 565,JAPAN
来源：
GROWTH FACTORS | 1994年 / 10卷 / 02期
关键词：
HEPATOCYTE GROWTH FACTOR; IN SITU HYBRIDIZATION; IMMUNOHISTOCHEMISTRY; SUBMANDIBULAR GLAND; RAT (WISTAR);
D O I：
10.3109/08977199409010988
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
By combination of in situ hybridization and immunohistochemical techniques, the expression of hepatocyte growth factor (HGF) was demonstrated in the submandibular gland of rats. Both the mRNA signal and immunoreactivity for HGF were localized exclusively to the epithelial cells of granular convoluted tubules, whereas they were absent from the other components of the submandibular gland. In the granular convoluted tubule cells, HGF-immunoreactivity was localized to the apical secretory granules, which was further substantiated by immunoelectron microscopy. These results added HGF to the list of many growth factors that are produced in the rat submandibular gland and secreted into the saliva.
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收藏
页码：145 / 151
页数：7
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