DECLINE IN MENINGOCOCCAL ANTIBODY-LEVELS IN AFRICAN CHILDREN 5 YEARS AFTER VACCINATION AND THE LACK OF AN EFFECT OF BOOSTER IMMUNIZATION

被引：43

作者：

CEESAY, SJ

ALLEN, SJ

MENON, A

TODD, JE

CHAM, K

CARLONE, GM

TURNER, SH

GHEESLING, LL

DEWITT, W

PLIKAYTIS, BD

GREENWOOD, B

机构：

[1] MRC LABS,POB 273,BANJUL,SENEGAMBIA

[2] MINIST HLTH,BANJUL,SENEGAMBIA

[3] CTR DIS CONTROL & PREVENT,ATLANTA,GA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1993年 / 167卷 / 05期

关键词：

D O I：

10.1093/infdis/167.5.1212

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibodies to group A meningococcal polysaccharide were measured by hemagglutination (HA) and by ELISA in sera obtained from Gambian children before vaccination and 3 weeks, 2 years, and 5 years after vaccination with a group A + group C meningococcal capsular polysaccharide vaccine. Children were 1-4 years old at the time of vaccination. Most showed a good initial response to vaccination, including those aged 1-2 years. However, antibody titers declined progressively during follow-up, and 5 years after vaccination, antibody titers measured by both HA and ELISA had returned to prevaccination levels. This decline was not influenced significantly by a booster dose of vaccine given 2 years after initial immunization. Administration of malaria chemoprophylaxis reduced the rate at which antibody levels fell after initial immunization. Sustained protection of children against group A meningococcal disease will require the development of vaccines that are immunogenic in infants and that can induce T cell memory.

引用

收藏

页码：1212 / 1216

页数：5

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