ISOLATION AND MAPPING OF 68 RFLP MARKERS ON HUMAN CHROMOSOME-6

被引：0

作者：

SAITO, S

OKUI, K

TOKINO, T

OSHIMURA, M

NAKAMURA, Y

机构：

[1] JAPANESE FDN CANC RES,INST CANC,DIV BIOCHEM,1-37-1 KAMI IKEBUKURO,TOSHIMA KU,TOKYO 170,JAPAN

[2] TOTTORI UNIV,DEPT MOLEC CELL GENET,TOTTORI 680,JAPAN

[3] SRL INC,TOKYO,JAPAN

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 1992年 / 50卷 / 01期

关键词：

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have isolated 68 new RFLP markers on human chromosome 6. Of these, 64 were localized on chromosomal bands by the fluorescent in-situ hybridization (FISH) method, 25 on the short arm and 39 on the long arm. Their distribution was uneven; the markers were localized predominantly in regions of R-positive banding. Eleven markers defined VNTR loci. This expanded collection of DNA markers will contribute to high-resolution linkage mapping of genes causing inherited disorders and will provide useful reagents for isolation of putative tumor-suppressor genes on chromosome 6 that appear to be involved in malignancies. Furthermore, the new markers will be guideposts for detailed linkage and physical maps of this chromosome.

引用

页码：65 / 70

页数：6

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