EDTA TREATMENT OF INTERMITTENT CLAUDICATION - A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY

被引：63

作者：

GULDAGER, B

JELNES, R

JORGENSEN, SJ

NIELSEN, JS

KLAERKE, A

MOGENSEN, K

LARSEN, KE

REIMER, KE

REIMER, E

HOLM, J

OTTESEN, S

机构：

[1] CENT HOSP HILLEROD,DEPT SURG,HILLEROD,DENMARK

[2] SKEJBY UNIV HOSP,DEPT SURG,AARHUS,DENMARK

[3] SLAGELSE HOSP,DEPT SURG,SLAGELSE,DENMARK

[4] AALBORG HOSP,DEPT VASC SURG V,DK-9000 AALBORG,DENMARK

[5] BISPEBJERG HOSP,DEPT SURG L,DK-2400 COPENHAGEN,DENMARK

[6] KOLDING CTY HOSP,DEPT SURG,KOLDING,DENMARK

[7] GENTOFE UNIV HOSP,DEPT SURG,COPENHAGEN,DENMARK

来源：

JOURNAL OF INTERNAL MEDICINE | 1992年 / 231卷 / 03期

关键词：

ATHEROSCLEROSIS; CHELATION THERAPY; ETHYLENEDIAMINE-TETRAACETICACID; INTERMITTENT CLAUDICATION;

D O I：

10.1111/j.1365-2796.1992.tb00533.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A double-blind, randomized multicentre study was undertaken to evaluate the possible effect of chelation treatment with ethylenediamine-tetraacetic acid (EDTA) in patients with severe intermittent claudication. A total of 153 patients received 20 intravenous infusions of either 3 g Na2EDTA or placebo during a period of 5-9 weeks. Vitamin, mineral and trace element supplements were administered orally. The changes observed in the pain-free and maximal walking distances, measured on a treadmill, were similar in the two groups. During the 3-month (n = 149) and 6-month (n = 123) follow-up period, no long-term therapeutic effect of EDTA could be demonstrated. The ankle-brachial blood pressure index remained unchanged throughout the study period. This study failed to demonstrate any effect of EDTA chelation treatment in intermittent claudication.

引用

页码：261 / 267

页数：7