INTERFERON-GAMMA MAY ENHANCE INFECTION OF BLOOD-DERIVED MACROPHAGES WITH HIV-1 IN THE PRESENCE OF HIV-POSITIVE SERUM

被引：7
|
作者：
DEGRE, M
BECK, S
ROLLAG, H
机构：
[1] Virology section, Wilhelmsens Institute of Bacteriology, University of Oslo, Rikshospitalet, Oslo
来源：
APMIS | 1992年 / 100卷 / 05期
关键词：
HIV-1; INFECTION; INTERFERON-GAMMA; FC-RECEPTOR; MACROPHAGES;
D O I：
10.1111/j.1699-0463.1992.tb00898.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
HIV multiplication in blood-derived macrophages was slightly inhibited by pretreatment of cells with interferon-gamma or by preincubation of virus with serum containing antibodies against HIV. When these pretreatments were combined, the HIV titres observed a short time after infection were enhanced. This effect was blocked by antibodies against Fc receptors but not by antibodies against CD4 receptors. Interferon enhanced the expression of Fc receptors on macrophages. The results indicate that IFN-gamma, in appropriate combinations with HIV-antibody-containing human serum, may enhance the rate of HIV infection of macrophages.
引用
收藏
页码：465 / 469
页数：5
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