DIFFERING LYMPHOKINE PROFILES OF FUNCTIONAL SUBSETS OF HUMAN CD4 AND CD8 T-CELL CLONES

被引：1048

作者：

SALGAME, P

ABRAMS, JS

CLAYBERGER, C

GOLDSTEIN, H

CONVIT, J

MODLIN, RL

BLOOM, BR

机构：

[1] DNAX RES INST MOLEC & CELLULAR BIOL INC, DEPT IMMUNOL, PALO ALTO, CA 94304 USA

[2] INST BIOMED, CARACAS, VENEZUELA

[3] STANFORD UNIV, MED CTR, DEPT CARDIOVASC SURG, PALO ALTO, CA 94304 USA

[4] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT MICROBIOL & IMMUNOL, BRONX, NY 10461 USA

[5] UNIV CALIF LOS ANGELES, SCH MED, DIV DERMATOL, LOS ANGELES, CA 90024 USA

[6] UNIV CALIF LOS ANGELES, SCH MED, DEPT MICROBIOL & IMMUNOL, LOS ANGELES, CA 90024 USA

来源：

SCIENCE | 1991年 / 254卷 / 5029期

关键词：

D O I：

10.1126/science.1681588

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-gamma, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-gamma. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.

引用

页码：279 / 282

页数：4

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