Photodynamic Therapy (PDT): PDT Mechanisms

被引：505

作者：

Allison, Ron R. ^{[1
]}

Moghissi, Keyvan ^{[2
]}

机构：

[1] 21st Century Oncol, Greenville, NC USA

[2] Yorkshire Laser Ctr, Goole DN14 6RX, East Yorkshire, England

来源：

CLINICAL ENDOSCOPY | 2013年 / 46卷 / 01期

关键词：

Photochemotherapy; Mechanisms; Photosensitizing agents; Photodynamic reaction;

D O I：

10.5946/ce.2013.46.1.24

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Photodynamic therapy (PDT) is a light based therapy used to ablate tumors. As practiced in oncology a photosensitizing agent is applied and then activated by a specific wavelength and energy of light. This light energy in the presence of oxygen will lead to the creation of the photodynamic reaction which is cyto and vasculo toxic. This paper will review the mechanisms of action of PDT and how they may be manipulated to improve clinical outcome in cancer patients.

引用

页码：24 / 29

页数：6

共 40 条

[1] Targeting of the vascular system of solid tumours by photodynamic therapy (PDT)
Abels, C
[J]. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2004, 3 (08) : 765 - 771
[2] AGARWAL ML, 1991, CANCER RES, V51, P5993
[3] Clinical PD/PDT in North America: An historical review
Allison, R. R.
Mota, H. C.
Sibata, C. H.
[J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2004, 1 (04) : 263 - 277
[4] Photofrin® photodynamic therapy:: 2.0 mg/kg or not 2.0 mg/kg that is the question
Allison, Ron R.
Sibata, Claudio H.
[J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2008, 5 (02) : 112 - 119
[5] Future of oncologic photodynamic therapy
Allison, Ron R.
Bagnato, Vanderlei S.
Sibata, Claudio H.
[J]. FUTURE ONCOLOGY, 2010, 6 (06) : 929 - 940
[6] Future PDT
Allison, Ron R.
[J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2009, 6 (3-4) : 231 - 234
[7] Photodiagnosis for cutaneous malignancy: A brief clinical and technical review
Allison, Ron R.
Sibata, Claudio H.
[J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2008, 5 (04) : 247 - 250
[8] Photosensitizers in clinical PDT
Allison, Ron R.
Downie, Gordon H.
Cuenca, Rosa
Hu, Xin-Hua
Childs, Carter J. H.
Sibata, Claudio H.
[J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2004, 1 (01) : 27 - 42
[9] Structure and biodistribution relationships of photodynamic sensitizers
Boyle, RW
Dolphin, D
[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1996, 64 (03) : 469 - 485
[10] Laser and non-laser light sources for photodynamic therapy
Brancaleon, L
Moseley, H
[J]. LASERS IN MEDICAL SCIENCE, 2002, 17 (03) : 173 - 186

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