SPECIFIC ANTAGONISM BY METOCLOPRAMIDE OF DOPAMINE-INDUCED RELAXATION ON ISOLATED RABBIT MESENTERIC-ARTERIES CONTRACTED WITH PROSTAGLANDIN-F2-ALPHA

被引：31
|
作者：
BRODDE, OE
SCHEMUTH, W
机构：
[1] Institute of Pharmacology, University of Essen, D-4300 Essen
来源：
LIFE SCIENCES | 1979年 / 25卷 / 01期
关键词：
D O I：
10.1016/0024-3205(79)90485-5
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
On isolated rabbit mesenteric arteries pretreated with phenoxybenzamine (10-5M) and contracted with prostaglandin F2α (PGF2α) dopamine (10-6M to 3×10-4M) and isoprenaline (10-9M to 10-5M) caused a dose-related relaxation. Pindolol (10-7M) significantly suppressed the effects evoked by isoprenaline, but did not affect those produced by dopamine. The dopamine receptor antagonist metoclopramide (5×10-5 and 10-4M), however, shifted the dose-response curve for dopamine-induced relaxation significantly to the right in a concentration dependent manner without affecting relaxations caused by isoprenaline or papaverine. These results demonstrate for the first time a specific antagonism to dopamine-induced relaxation on rabbit mesenteric arteries in vitro. They support the hypothesis of the existence of specific dopamine receptors in vascular smooth muscles. © 1979.
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页码：23 / 30
页数：8
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