SPECIFIC ANTAGONISM BY METOCLOPRAMIDE OF DOPAMINE-INDUCED RELAXATION ON ISOLATED RABBIT MESENTERIC-ARTERIES CONTRACTED WITH PROSTAGLANDIN-F2-ALPHA

被引：31

作者：

BRODDE, OE

SCHEMUTH, W

机构：

[1] Institute of Pharmacology, University of Essen, D-4300 Essen

来源：

LIFE SCIENCES | 1979年 / 25卷 / 01期

关键词：

D O I：

10.1016/0024-3205(79)90485-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

On isolated rabbit mesenteric arteries pretreated with phenoxybenzamine (10-5M) and contracted with prostaglandin F2α (PGF2α) dopamine (10-6M to 3×10-4M) and isoprenaline (10-9M to 10-5M) caused a dose-related relaxation. Pindolol (10-7M) significantly suppressed the effects evoked by isoprenaline, but did not affect those produced by dopamine. The dopamine receptor antagonist metoclopramide (5×10-5 and 10-4M), however, shifted the dose-response curve for dopamine-induced relaxation significantly to the right in a concentration dependent manner without affecting relaxations caused by isoprenaline or papaverine. These results demonstrate for the first time a specific antagonism to dopamine-induced relaxation on rabbit mesenteric arteries in vitro. They support the hypothesis of the existence of specific dopamine receptors in vascular smooth muscles. © 1979.

引用

页码：23 / 30

页数：8

共 15 条

[1]

COHEN ML, 1974, J PHARMACOL EXP THER, V191, P147

[2] CARDIOVASCULAR DOPAMINE RECEPTOR STIMULATION ANTAGONIZED BY METOCLOPRAMIDE [J].